Top: β-lactam antimicrobial agents rupture bacteria by destroying their cell walls. Bottom: The red text in the structural formula represents the β-lactam ring, which is essential for bactericidal ...

Led by Director CHANG Sukbok, scientists from the Center for Catalytic Hydrocarbon Functionalizations within the Institute for Basic Science (IBS) have made a significant advancement in the synthesis ...

Synthetic chemists can go around in circles trying to make the cyclic amides known as lactams. That’s because lactams with 4-, 5-, and 6-membered rings—known as β-, γ- and δ-lactams, respectively—are ...

In patients with suspected sepsis, the use of β-lactam therapy prior to vancomycin was associated with lower risk of in-hospital mortality compared with vancomycin prior to β-lactam therapy. The ...

Scientists have developed a new, highly sensitive analytical method that can detect degraded beta-lactam antibacterial agents used in the treatment of bacterial infections. With this method, ...

A joint research project based in Kumamoto University, Japan has developed a new, highly sensitive analytical method that can detect degraded β-lactam antibacterial agents used in the treatment of ...