What started as a trickle of data is turning into a rivulet, and may become a stream before long as more and more researchers are testing the idea that β-secretase enzyme activity in cerebrospinal ...

The β-secretase enzyme BACE1 become an instant favorite among researchers interested in developing small-molecule drugs against Alzheimer's disease when it was cloned by researchers at Amgen and even ...

Researchers from the Cleveland Clinic have reversed the development of amyloid plaque in mice with Alzheimer’s disease by gradually depleting their levels of BACE1. The study buoys hope that targeting ...

Researchers have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease, thereby improving the ...

Researchers working at Lerner Research Institute, Cleveland Clinic reported in the November 8, 2021, issue of Nature Cancer that an inhibitor of the beta-amyloid producing enzyme, BACE1, could ...

Merck ($MRK) has posted a roundup of data generated to date on its BACE1 inhibitor in Alzheimer’s disease tests and trials. The package includes results from a ...

A new study has successfully reversed both the biological and behavioral hallmarks of Alzheimer's disease in mouse models. The research found that slowly depleting the presence of a certain enzyme can ...

Researchers at the RIKEN-Max Planck Joint Research Center in Japan have demonstrated that hallmark symptoms of Alzheimer's disease can be reduced when sugars are prevented from binding to one of the ...

Sluggish recycling of a protein-slicing enzyme could promote Alzheimer's disease, according to a study published online on November 21 in The Journal of Cell Biology (www.jcb.org). Abeta, the toxic ...

We first examined whether BACE1 and α-secretase activities could generate two C-terminal fragments (CTFs) of β2 corresponding to the individual cleavage products of β- and α- secretase. Two β2-CTFs ...