About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). GPCRs are indispensable for ...

Understanding what causes a compound to be a biased modulator is a key step in enabling the design of compounds with more precision in the array of G proteins that they activate. The scientists ...

Carmot Therapeutics is catching up to companies with drugs designed to hit receptors that have become hot targets for metabolic diseases such as diabetes and obesity. But clinical-stage Carmot ...

This is a preview. Log in through your library . Abstract G protein–coupled receptors (GPCRs) are involved in regulation of manifold physiological processes through coupling to heterotrimeric G ...

Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs ...