Nature

Enhancement of binding activity of soluble human CD40 to CD40 ligand through incorporation of an isoleucine zipper motif

To investigate the effect of incorporation of an isoleucine zipper (IZ) motif into CD40 on binding activity of CD40 for the CD40 ligand (CD40L). Prokaryotic expression vectors for 2 soluble CD40 ...
Nature

The Hyper IgM Syndrome—An Evolving Story

In 1961, Rosen et al. (1) described two brothers with recurrent infections, and Burtin (2) reported a similar patient who had low levels of 7S gamma-globulin (IgG) and elevated 19S gamma-globulin (IgM ...
ascopubs.org

Single Nucleotide Polymorphisms in CD40L Predict Endothelial Complications and Mortality After Allogeneic Stem-Cell Transplantation

Predictors of Specialized Pediatric Palliative Care Involvement and Impact on Patterns of End-of-Life Care in Children With Cancer Three CD40L SNPs (rs3092920, rs3092952, rs3092936) were analyzed for ...
BioWorld

Small-molecule CD40-CD40L interaction inhibitors show promise in islet transplantation mouse models

Scientists from the Miller School of Medicine at the University of Miami have reported their recent work to develop small-molecule inhibitors of the CD40-CD40L (CD154) costimulatory protein-protein ...
MedPage Today

Novel Drug Shows Promise in Multiple Sclerosis

MILAN -- Treatment with investigational frexalimab, a novel CD40 ligand (CD40L) inhibitor, led to sustained reduction of MRI disease activity in relapsing multiple sclerosis (MS) at 6 months, ...
MedPage Today

Novel Anti-CD40L Antibody Slows New Brain Lesions in Relapsing MS

Frexalimab, an investigational second-generation CD40 ligand (CD40L) inhibitor, led to fewer new gadolinium-enhancing T1-weighted lesions in relapsing multiple sclerosis (MS), a phase II trial showed.
PharmiWeb

CD40:CD40L as a target for Alzheimers...A new candidate oncology therapeutic to enter the clinic

PharmiWeb.com is Europe's leading industry-sponsored portal for the Pharmaceutical sector, providing the latest jobs, news, features and events listings. The information provided on PharmiWeb.com is ...
PharmiWeb

Lundbeck receives exclusive rights to APB-A1, an innovative phase I-ready bio-therapeutic for the treatment of neuroimmune diseases from AprilBio

APB-A1 targets the clinically validated CD40L/CD40 biology which is central to a wide range of attractive neuroimmune indications APB-A1 is a novel and differentiated biotherapeutic with strong ...
Healio

Anti-CD40L antibody frexalimab significantly reduced T1 lesions in relapsing MS

Please provide your email address to receive an email when new articles are posted on . Disease activity in relapsing MS patients significantly fell following treatment with frexalimab, a novel second ...
PR Newswire

CD40/CD40L Inhibitors Market on Growth Trajectory Driven by Advancements in Autoimmune and Cancer Therapeutics | DelveInsight

The CD40/CD40L inhibitors market is experiencing steady growth driven by increasing research into autoimmune diseases, organ transplantation, and cancer immunotherapy. The rising prevalence of ...
ascopubs.org

Single Nucleotide Polymorphisms in CD40L Predict Endothelial Complications and Mortality After Allogeneic Stem-Cell Transplantation

Predictors of Specialized Pediatric Palliative Care Involvement and Impact on Patterns of End-of-Life Care in Children With Cancer Endothelial vulnerability is a potential risk factor for ...