Researchers from the University of Copenhagen have mapped the structure of an important channel in human muscle cells. The new insights about the chloride channel can contribute to greater ...

Chloride channels, particularly those of the CLC family, are vital for cellular homeostasis by facilitating the exchange of chloride ions and protons across membranes. These transport proteins govern ...

Nerve cells communicate with each other by means of electrical impulses. To create such an impulse, the cells exchange charged ions with their environment. However, the role played by the ever-present ...

Chloride channels are integral membrane proteins that facilitate the passage of chloride ions across cellular membranes, contributing fundamentally to cell volume regulation, transepithelial transport ...

Scientists have generated structural images of a newly-described class of ion channels that help maintain the balance of pH inside brain cells. These molecular gates, called proton-activated chloride ...

In the human body the salt content of cells and their surrounding is regulated by sophisticated transport systems. Special channels in the cell membrane selectively permit salt ions to flow in and out ...

Laboratory cell experiments and computer simulations have revealed molecular mechanisms regulating a protein channel responsible for transporting chloride and other charged molecules across cell ...

When the adrenal gland produces too much aldosterone, this often leads to high blood pressure and kidney damage (hyperaldosteronism). It has only recently emerged that several patients harbor a ...

Rodent ClC-K1 and ClC-K2, and their respective human orthologs ClCKA and ClCKB, are chloride channels specific to the kidney (and inner ear); Barttin is their functionally important subunit. ClC-K1 is ...

When the adrenal gland produces too much aldosterone, this often leads to high blood pressure and kidney damage (hyperaldosteronism). It has only recently emerged that several patients harbor a ...

In the cells of the Arabidopsis plant, exposure to sodium chloride (NaCl) induces the movement (translocation) of the green fluorescent protein (GFP) tagged chloride channel, GFP-AtCLCf, from the ...