Some of the signs of aging in human cells originate in the cell nucleus, because the packaged form of DNA changes with age.

Genome-wide chromatin accessibility profiling reveals how myelodysplastic syndrome (MDS) stem cells progressively lose normal stem-cell features and acquire myeloid progenitor-like characteristics.

Life begins with a quiet but precise choreography inside the nucleus. For decades, scientists believed that a newly ...

A novel, freely available AI tool has cut the time it takes to determine chromatin structure from days to minutes. The 3D structure of DNA is important for controlling cell-specific gene expression ...

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) have identified key changes to both chromosome structure and gene expression that affect stem cell function during aging. Using ...

Maize serves as a vital model species for advancing our understanding of plant biology, yet many mysteries remain about the ...

Scientists reveal a hidden second layer of human DNA, showing how genome folding controls genes and influences disease development.

Complementary value of a digital pathology biomarker to post-surgery circulating tumor DNA in risk stratification of stage III colon cancer patients receiving adjuvant chemotherapy. This is an ASCO ...

A single-cell atlas of brain aging epigenetics has mapped methylation, chromatin, and gene activity changes across 36 cell ...