The US Food and Drug Administration has approved Merck & Co.’s cyclic peptide enlicitide decanoate for the reduction of ...

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...

Cyclic peptides represent a versatile class of macrocyclic compounds formed by head-to-tail cyclisation of linear amino acid sequences or by incorporation of non-proteinogenic residues. Advances in ...

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed a sustainable, biodegradable, biorecyclable material: high-entropy non-covalent cyclic ...

Cyclic peptides, in which the N- and C-termini or side chains are covalently linked to form a ring, have emerged as versatile scaffolds for applications ranging from drug design to materials science.

Scientists have developed stable orally available cyclic peptides with a much higher bioavailability than current ones, virtually creating a generation of drugs that can target previously untreatable ...

Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is difficult because typical "small-molecule" drugs often prove to be too ...

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ...

A research team at CiQUS (University of Santiago de Compostela, Spain) has unveiled an innovative molecular approach that enables anticancer drugs to reach the nucleus of tumor cells, where they can ...

The University of California, Berkeley, has spun out Insamo, a start-up focused on making oral cyclic peptides, which would replace medicines that have so far only been available as injections or ...

Bivision Pharmaceuticals (Shanghai) Co. Ltd. has identified cyclic peptides targeting fibroblast activating protein α (FAP) reported to be useful for the treatment of cancer.

Peptides, as essential biomolecules linking amino acids and proteins, play a vital role across numerous disciplines, including life science research, drug discovery, biomaterials engineering, and ...