Eukaryotic chromosomes replicate from multiple discrete loci termed origins of replication. These sites are first recognised by the origin recognition complex (ORC), which, together with Cdc6 and Cdt1 ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Every time a cell copies its DNA, parts of the genome are exposed and vulnerable to damage or errors. Molecular biologist ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...

For almost 60 years, scientists have tried to understand why DNA doesn’t replicate wildly and uncontrollably every time a cell divides – which they need to do constantly. Without this process, we ...

The herpesvirus can manipulate our DNA with far more precision than previously thought. The virus condenses and changes the shape of our genetic material to hijack the host genes needed for ...

Researchers at The University of Texas MD Anderson Cancer Center have identified a key enzyme—RNase H2—that helps triple-negative breast cancer (TNBC) cells survive high levels of DNA replication ...

DNA replication in eukaryotic cells is a highly coordinated, multi-step process that ensures precise duplication of the genome prior to cell division. In late mitosis and early G1 phase, the Origin ...