Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, in collaboration with Osaka University and ...

Cell surface receptors, such as the G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK), play central roles signalling pathways. Due to their central role in regulating a wide range ...

What is dimerization? It is a process where two molecules of similar chemical composition come together to form a single polymer known as a dimer. Where does dimerization occur? It happens throughout ...

Microscopic image showing parts of the HER2 receptor touching each other inside the cells (green) and outside the cells (red) in a process called dimerization. The lack of red shows that cells with ...

The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive ...

A dream drug would provide a targeted therapeutic effect without side effects. Biased signalling, whereby certain cellular signalling pathways are favoured over others, could make this a reality. Now, ...

Two new Yale-led studies elucidate protein structure and function of ALK, a protein receptor, which could contribute to new treatments for pediatric neuroblastoma and lymphoma. Two new Yale-led ...