Medscape

Association of Core Promoter Mutations With Viral Breakthrough in Chronic Hepatitis B Patients on Long-term Lamivudine

Patients with chronic hepatitis B virus infection with histological evidence of chronic hepatitis who were on long-term lamivudine therapy (≥12 months) were screened. Patients who had at least one ...
Nature

Longitudinal Study on Mutation Profiles of Core Promoter and Precore Regions of the Hepatitis B Virus Genome in Children

Hepatitis B e antigen (HBeAg), coded by the precore and core genes, is an important infectivity marker in hepatitis B virus (HBV) infection. HBeAg has been suggested to be a target of host cytotoxic T ...
EurekAlert!

Paclitaxel-induced immune dysfunction and activation of transcription factor AP-1 facilitate Hepatitis B virus replication

PTX-induced HBV reactivation was likely a synergistic outcome of immune suppression and direct stimulation of HBV replication through the enhancement of HBV core promoter activity mediated by the ...
JSTOR Daily

N6-methyladenosine modification of the 5′ epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein

Hepatitis B virus (HBV) contains a partially double-stranded DNA genome. During infection, its replication is mediated by reverse transcription (RT) of an RNA intermediate termed pregenomic RNA (pgRNA ...
News Medical

Paclitaxel treatment found to directly promote HBV replication and transcription

Hepatitis B virus (HBV) reactivation is commonly observed in individuals with chronic HBV infection undergoing antineoplastic drug therapy. Paclitaxel (PTX) treatment has been identified as a ...
Medscape

Strategies to Eliminate HBV Infection

AT-61; AT-130 Inhibit HBV virion production by inappropriate assembly of capsids (no clinical data available yet) Induces structural changes in HBV capsids; initiates virion assembly at wrong point in ...