The intracellular termini of the hERG channel are also important for function. The N-terminus contains a Per-Arnt-Sim (PAS) domain (about 135 amino acids), which, despite being a common motif in ...

Expert Rev Clin Pharmacol. 2010;3(3):321-329. Torsades de pointes (TdP) arrhythmia is a potentially life-threatening cardiac disorder that is often associated with a prolonged QT interval in the ...

hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to ...

MHRA has made the company a member of the UK GLP compliance monitoring programme MHRA has made the company a member of the UK GLP compliance monitoring programme Metrion Biosciences, a company focused ...

Repolarization abbreviation with the antiarrhythmic drug mexiletine has been found to normalize the QTc interval and reduce the rate of events in long QT syndrome type 3 (LQT3), but it is only ...

Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced it has received notification from the UK’s Medicines and Healthcare ...

Expert Rev Clin Pharmacol. 2010;3(3):321-329. Despite a propensity to block hERG channel function, as determined by electrophysiology, for a limited number of compounds no cardiac arrhythmias have ...

Metrion Biosciences Limited (“Metrion”), announced it has received notification from the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) that the Company is now a member of the UK GLP ...