The orange wheel shows the circular chromosome or genome of E. coli bacteria. The spikes indicate where a molecular intermediate in DNA repair -- four-way DNA junctions -- accumulate near a reparable ...

(A) Electron-microscope image of a recombination intermediate. In this image, the Holliday junction was partially denatured to assist its visualization. (B) Two possible configurations for the ...

Holliday junctions are central intermediates in homologous recombination, characterised by a four-way DNA structure whose dynamics underpin genetic exchange, DNA repair and genome stability across all ...

Researchers explore a basic building block used in the fabrication of many DNA nanoforms. Known as a Holliday junction, this nexus of two segments of double stranded DNA has been used to form ...

Every new life begins after a genetic shuffle. When organisms make eggs or sperm, maternal and paternal chromosomes pair up and swap pieces of DNA in a process called crossing over. This exchange is ...

In the world of biomolecules, none is more iconic, nor more versatile, than DNA. Nature uses the famous double helix to store the blueprints of all living forms, drawing on a four-letter alphabet of ...