Healthy digestion depends on a delicate balance of fluid in the gut. At the heart of that balance are epithelial cells, which line the intestinal wall and control how salt and water move in and out of ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

This study is led by Professor Fachao Zhi's research team from Nanfang Hospital, Southern Medical University. This study utilizes Western diet-fed mice to determine the role that the Western Diet ...

Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme OGDH ...

On the left, large intestine tissue from a healthy person; on the right, from a patient with active C. difficile infection. The white areas show the cells that line the intestine (epithelial cells).

Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how much ...