Tight junctions are crucial for maintaining intestinal barrier homeostasis, but how organisms modulate these junctions remain unclear. Here, we show a role for PEAK1 at cell-cell contact sites, where ...
To assess whether IEC-specific deletion of Jak2 affects growth over time, body weight was measured in vJAK2 KO and vJAK2 WT littermates at 2, 4, 8, and 12 weeks of age. Although body weight trended ...
A research team led by scientists from the State University of Campinas (UNICAMP) in São Paulo, Brazil, has made significant progress in understanding the relationship between gut microbiota and ...
A new preclinical study from Weill Cornell Medicine found that the protein caspase-5 (CASP5), long thought to be a foot soldier in the body's defense against bacterial infection, does not actually ...
Chinese Medical Journals Publishing House Co., Ltd. The small intestine is not only essential for digestion and nutrient absorption but also for immune regulation and maintaining a balanced microbial ...
Tuft cells are present throughout the intestinal tract as well as in many organs. Studies in mice have shown that when tuft cells sense the presence of pathogens, they signal to immune cells and to ...
Paneth cell metaplasia (PCM), long viewed as a consequence of chronic inflammation in ulcerative colitis, may also help ...
Researchers from the Hebrew University of Jerusalem and the Weizmann Institute of Science have identified a previously unrecognized defense mechanism in the intestine, showing that intestinal stem ...
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