Autism spectrum disorder (ASD) is a complex neurodevelopmental condition in which affected individuals experience difficulties in social communication and exhibit restricted, repetitive patterns of ...
CD2AP and Alzheimer’s disease: A key regulator of neurodegeneration and potential therapeutic target
Impact of CD2AP deficiency in microglia in Alzheimer’s disease (AD). Microglial CD2AP levels are increased in AD, leading to elevated CSF1R signaling and C1q expression and cytoskeleton remodeling in ...
The powerful, and often shifty, role that microglia play in Alzheimer’s and other neurodegenerative diseases is a topic of intense study. However, as demonstrated by presentations at the AD/PD meeting ...
The Alzheimer’s risk gene phospholipase C-γ2 has been thought to act mainly in microglia. Now, in a May 1 preprint on bioRxiv, researchers led by Jean-Charles Lambert, Julie Dumont, and Julien Chapuis ...
In a recent study published in the journal Nature, a group of researchers investigated how aging alters neuronal protein degradation, aggregation, and transfer to microglia, with a focus on synaptic ...
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