Bladder small-cell carcinoma can be divided into different subtypes depending on the expression of neuroendocrine (NE) markers such as POU2F3, NEUROD1 and ASCL1. Single-cell RNA sequencing previously ...

The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare variant in this gene, P522R, has been ...

Testosterone Replacement Therapy and Risk of Favorable and Aggressive Prostate Cancer Patients accrued to four sequential studies of ibrutinib were included in these analyses. Deep sequencing for BTK ...

A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer's disease, enhances several key functions of ...

A new study has found that the PLCG2-P522R genetic variant, which protects against Alzheimer's disease, enhances several key functions of immune cells. The results obtained in the study highlight the ...

Different variants in the gene encoding phospholipase C-γ2—an enzyme expressed in microglia—can either raise the risk of AD, or protect against it. According to a study published September 12 in ...

Research presented at Alzheimer’s Association International Conference (AAIC) today shows that a genetic variant of the PLCG2, a gene previously associated with risk of Alzheimer’s Disease, may reduce ...

A team of Case Western Reserve University researchers has identified a new gene associated with advanced age-related macular degeneration (AMD), the leading cause of blindness in the elderly, ...