DES MOINES, Iowa — Liquor was always more than a drink for Ames resident J. Hans van Leeuwen. It was a science experiment, and, to him, the distillation process longed for further perfection. As a boy ...

Mineral oil hydrocarbons (MOH) are extensively utilized as lubricants and may contain mutagenic and carcinogenic impurities. Therefore, food safety authorities mandate testing ingredients, finished ...

Quantitative analysis of volatile nitrosamine impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over ...

As technology for impurity analysis improves, scientists are gaining better information and asking for more regulatory guidance. Even at minute quantities, unwanted chemicals present in pharmaceutical ...

Samples for EI, or APPI (solid probe) analysis must be neat, solvent-free, and reasonably pure. It must be possible to introduce them into a fine capillary tube. These ionization methods can tolerate ...

Nitrosamine impurities became a topic of focus when health regulators recalled valsartan, an antihypertensive drug, due to the presence of N-nitrosodimethylamine (NDMA), a probable carcinogenic agent ...

This case study highlights analytical instrumentation and techniques that were used to identify an unknown impurity detected during routine release testing of a topical gel drug product. It is not ...