DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

Scientists from Oxford's Radcliffe Department of Medicine have achieved the most detailed view yet of how DNA folds and functions inside living cells, revealing the physical structures that control ...

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...

DNA isn't just a long string of genetic code, but an intricate 3D structure folded inside each cell. That means the tools used to study DNA need to be just as sophisticated-able to read not only the ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

This important study, which tackles the challenge of analyzing genome integrity and instability in unicellular pathogens by introducing a novel single-cell genomics approach, presents compelling ...

New work from UC Davis and the University of Utah shows how the 3D structure of DNA inside a germ cell commits it to develop into a sperm cell. The discovery could improve understanding of fertility ...

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To our immune system, a potentially lifesaving gene therapy can look a lot like a dangerous infection. That's because most genetic medicine uses viruses or double-stranded DNA to deliver genetic ...