Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. It plays a major role in the regulation of embryonic …

Mar 24, 2022 · We summarized both classical and cutting-edge findings of NOTCH signaling in this review, illustrating the history, architecture, regulatory mechanism, physiology, and pathology of …

This Special Issue titled “Notch Signaling in Health and Disease” delves into the diverse roles of the Notch signaling pathway in various physiological and pathological contexts.

2 days ago · Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and maintains adult tissue homeostasis.

The Notch signaling pathway is a communication system between cells that regulates various cellular processes, including cell proliferation, differentiation, and cell fate determination. It is also crucial for …

Mar 10, 2025 · This Review discusses how different modes of Notch signalling can have different functional outcomes, and how their dysregulation is associated with cancer states.

The direct translocation of an active Notch signaling fragment to the nucleus is arguably the most striking feature of Notch signaling, and sets this pathway apart from those that rely upon multiprotein …

Notch signaling involves a series of interactions between cells that can determine how they behave, divide, or differentiate. Thus, studying the Notch pathway offers insights not only into normal …

May 16, 2024 · Since its discovery at the beginning of the 20th century, the Notch signaling pathway has been demonstrated as one of the main cell–cell communication channels across metazoans.

When the cell-surface receptor Notch interacts with a ligand (e.g., Delta), its intracellular domain is cleaved and travels to the nucleus to regulate transcription. This influences cell division, fate, and …