kCNH2 - Wikipedia
This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel mediates the repolarizing IKr current in the cardiac …
hERG toxicity assessment: Useful guidelines for drug design
Jun 1, 2020 · All along the drug development process, one of the most frequent adverse side effects, leading to the failure of drugs, is the cardiac arrhythmias. Such failure is mostly related to the …
hERG toxicity prediction in early drug discovery using extreme gradient ...
May 4, 2025 · Blockade of the human Ether-à-go-go Related Gene (hERG) potassium channel by small molecules can prolong the QT interval, leading to fatal cardiotoxicity. Numerous drugs have been …
What Are hERG Channels and Why Are They Important?
Jun 15, 2025 · One particular gate, the human Ether-à-go-go-Related Gene (hERG) channel, is a specific type of potassium ion channel. Found primarily in the muscle cells of the heart, its correct …
An Update on the Structure of hERG - Frontiers
Jan 24, 2020 · In this light, a recent cryo-EM structure for hERG (Wang and MacKinnon, 2017) is very welcome, providing the potential to facilitate major advances in understanding hERG drug block and …
Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG
The human ether-à-go-go -related potassium channel (hERG, Kv11.1) is a voltage-dependent channel known for its role in repolarizing the cardiac action potential. hERG alteration by mutation or …
Med Chem Strategies to Master hERG and Mitigate Cardiotoxicity Risks
Nov 26, 2024 · In recent years, cryo-EM structures of the full hERG channel have been published, providing invaluable insights and confirming many prior hypotheses about hERG inhibition. The …
Medchem Concepts – hERG, what is it and how to design it out?
hERG, or human Ether-à-go-go-Related Gene, encodes for a potassium ion channel in the heart. This channel is responsible for regulating the flow of potassium ions across cell membranes, which plays …
hERG K+ Channels: Structure, Function, and Clinical Significance ...
Abstract The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K + channel, Kv11.1, which are expressed in the heart, various …
hERG toxicity assessment: Useful guidelines for drug design
Jun 1, 2020 · A wide array of hERG structure resolutions have been carried out but still without available hERG crystal. Herein, we enumerate and analyze all the body of knowledge on hERG structure until …